Working with Insoluble Compounds

Working with Insoluble Compounds 2018-01-12T20:26:34+00:00

More than 40% NCEs (new chemical entities) developed in the pharmaceutical industry are practically insoluble in water. These poorly water soluble drugs having slow drug absorption lead to inadequate bioavailability and gastrointestinal/mucosal toxicity.  Selection of a specific solubility improving method will depend on drug property, site of absorption, and required dosage form characteristics.

Techniques for Solubility Enhancement

  • Physical Modifications: Particle size reduction (micronization and nanosuspension), crystal modification (polymorphs), amorphous form and co-crystallization, drug dispersion in carriers (eutectic mixtures), solid dispersions, solid solutions and cryogenic techniques.
  • Chemical Modifications: pH stability, buffer optimization, chemical complexation and salt formation.
  • Custom Methods: Supercritical fluid process, co-solvency, addition of surfactants, solubilizers, and other novel excipients.

At VxP Pharma, we can quickly address and repair your solubility issues for practically every available dosage form. We have extensive experience working with insoluble compounds from early concept to clinical trial materials. We have many tricks and tools at our disposal that we have used to solubilize and tame even the most “brick-dust-like” compounds.

Our state-of-the-art labs are staffed by some of the best trained and most experienced subject matter experts in the field.

Contact us today for a free consultation with our scientific team and discover how VxP can be a valuable resource and partner for your organization.