CNS 2013-02-04T11:10:51+00:00

At VxP Pharma, a complete range of in-vivo pharmacology services are available to support animal models, pre-clinical studies and/or clinical trials.  Our exceptional team of scientists including toxicologists, pathologists, veterinary surgeons, regulatory specialists, and support personnel have designed and performed pharmacological testing on numerous individual study designs enabling our clients to quickly meet their product development goals.  We can customize our in-vivo laboratory services to meet your unique objectives in a variety of different animal models, to provide efficacy, pharmacokinetic, or toxicity data.

Due to the importance of translation science in CNS drug discovery we have built a broad spectrum of animal models for CNS diseases to provide systematic in vivo drug discovery and development service with multiple endpoints including: behavior, efficacy, PK/PD, safety, biomarkers assay, and pathology.

Translational models of CNS/Pain

  • Monosodium Iodacetate (MIA)
  • In-vivo brain receptor occupancy measurement

CNS Models & Measurements

  • Safety assays
    • Irwin test
    • FOB (functional observational battery)
    • Spontaneous locomotor activity
    • Rotarod test
    • Grip strength
  • Cognitive function assays
    • Morris water maze
    • Passive avoidance
    • Delayed alteration task (Y-maze)
    • Novel object recognition (NOR)
    • Attentional set shifting
  • Schizophrenia
    • Pre – pulse inhibition of startle (PPI)
    • Conditioned avoidance response (CAR)
    • PCP or Amphetamine induced hyper-locomotor activity
    • Sub – PCP or Neo – PCP induced cognitive deficits
  •  Anxiety and Depression
    • Vogel conflict test
    • Open field
    • Elevated plus maze
    • Forced swimming test
    • Learned helplessness
  • Parkinson’s Disease (PD)
    • HIC (haloperidol induced catalepsy)
    • 6-OHDA unilateral lesion model
    • Akinesia model in 6 – OHDA PD rats
    • L – DOPA induced dyskinesia in 6 – OHDA PD rats
  • Alzheimer’s Disease (AD)
    • Scopolomine induced amnesia models

At VxP Pharma, we understand your needs and have the extensive experience working with the FDA, USDA, and EPA required to make your animal research projects a success.  Specifically tailored, individual study designs enable our clients to meet their product development goals and facilitate world-wide regulatory approval.  Our individualized approach to each study allows us to revise and shift directions based on your changing needs.

Our state-of-the-art labs are staffed by some of the best trained and most experienced subject matter experts in the field.

Contact us today for a free consultation with our scientific team and discover how VxP can be a valuable resource and partner for your organization.