Pain 2013-02-04T11:11:25+00:00

At VxP Pharma, a complete range of in-vivo pharmacology services are available to support animal models, pre-clinical studies and/or clinical trials.  Our exceptional team of scientists including toxicologists, pathologists, veterinary surgeons, regulatory specialists, and support personnel have designed and performed pharmacological testing on numerous individual study designs enabling our clients to quickly meet their product development goals.  We can customize our in-vivo laboratory services to meet your unique objectives in a variety of different animal models, to provide efficacy, pharmacokinetic, or toxicity data.

Due to the importance of translation science in pain drug discovery we have built a broad spectrum of animal models for chronic pain to provide systematic in vivo drug discovery and development services with multiple endpoints including: behavior, efficacy, PK/PD, safety, biomarkers assay, and pathology.

Translational Models of CNS/Pain

  • Monosodium Iodoacetate (MIA)
  • In-vivo brain receptor occupancy measurement

Pain Models & Measurements

  • Acute nociception
    • Tail flick
    • Hot plate
  • Acute inflammatory pain
    • Formalin
    • Capsaicin induced tactile allodynia
    • Carrageenan
  • Chronic inflammatory pain
    • CFA
  • Chronic neuropathic pain
    • SNL: spinal nerve ligation (Chung)
    • CCI: chronic constriction injury
    • PNL: partial nerve ligation
    • Diabetic/chemotherapy pain
  • Post – surgical pain
    • Brennan model in rats
  • Visceral pain
    • Acetic acid writhing in mice
  • Itching model
    • Compound 48/80 induced itching model in mice

At VxP Pharma, we understand your needs and have the extensive experience working with the FDA, USDA, and EPA required to make your animal research projects a success.  Specifically tailored, individual study designs enable our clients to meet their product development goals and facilitate world-wide regulatory approval.  Our individualized approach to each study allows us to revise and shift directions based on your changing needs.

Our state-of-the-art labs are staffed by some of the best trained and most experienced subject matter experts in the field.

Contact us today for a free consultation with our scientific team and discover how VxP can be a valuable resource and partner for your organization.