The selection of a lead drug candidate can be one of the most challenging and rewarding decisions made at the preclinical stage. From initial target identification and screening to lead optimization and selection, our chemistry team can provide the most effective support throughout every step of the drug discovery process. With over one hundred thousand steps of custom syntheses already completed for other clients, you can have confidence that our expertise will provide the most time efficient and cost effective novel compound production for your development needs.
At VxP Pharma, we believe the most fruitful approach to selecting new drug candidates is to identify key issues of the lead compound based on early screening data, and then to focus on exposing any serious deficits that would otherwise hinder successful development, bearing in mind (structure-activity relationship) SAR data for the pharmacological target. By obtaining SAR data in the discovery phase, potentially serious liabilities in a given structural series become evident at the outset, and informed decisions can be made accordingly to redirect chemistry efforts in order to prevent costly mistakes in early development.
We can support:
- custom synthesis
- preclinical candidate selection
- SAR data
By letting us evaluate and develop the pharmacological, pharmacokinetic, metabolic, and toxicological profiles of your lead candidate, we can focus on minimizing deficiencies early on through strategic chemical intervention, in which your development resources are conserved as a result.
The state-of-the-art labs are staffed by some of the best trained and most experienced subject matter experts in the field.