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Blog 2018-03-04T18:00:46+00:00
1804, 2018

Ophthalmic Formulation Development

By | April 18th, 2018|Categories: Formulation Development & Clinical Trial Materials, Ophthalmic|Tags: , , , , , |0 Comments

Formulations intended for ocular delivery must comply with a wide range of guidelines, both physiological and regulatory. Ophthalmics remain one of the most successful categories of pharmaceuticals worldwide, with a market cap of at least $17 billion, and a compound annual growth rate (CAGR) of six percent. In contrast with [...]

504, 2018

3 Challenging Complexities of Preclinical Toxicology Studies

By | April 5th, 2018|Categories: Formulation Development & Clinical Trial Materials|Tags: , , , |0 Comments

Each phase of tox screening introduces unique variables into the process, demanding agility and expertise from testing teams. by Susan Thompson, Technical Director at VxP Pharma Once a drug formulation has demonstrated its viability as a potential candidate for clinical applications, it must be vetted for potential toxicity to animal [...]

504, 2018

Critical Reasons to Invest in Pharmaceutical Analytical Services

By | April 5th, 2018|Categories: Formulation Development & Clinical Trial Materials|Tags: , , , , , , |0 Comments

From screening to development to manufacturing, analytical partners provide invaluable insights. Traditional pharmaceutical manufacturing has always involved a certain amount of trial and error. Polymorphs and biological molecules are screened as they're detected. Pilot batches are analyzed as they emerge from the chamber. Cleanrooms and pipelines are adapted as needs [...]

404, 2018

Quality Standards to Consider When Selecting a Sterile CMO

By | April 4th, 2018|Categories: Generic & Commercial Drug Manufacturing Services|Tags: , , |0 Comments

Your manufacturing partner should demonstrate commitments to transparency and consistency, along with awareness of today’s regulatory landscape. The global market for sterile injectables continues to expand at an impressive rate. In 2015, this market was valued at $299.7 billion; and its compound annual growth rate (CAGR) is projected at 6.9 [...]

404, 2018

Five Crucial Areas of Concern in Any GLP Lyophilization Process

By | April 4th, 2018|Categories: Lyophilization|Tags: , , |0 Comments

Although lyophilization (freeze-drying) is a costly, time-consuming process, it offers a number of major advantages over simpler dosage forms. Tablets and capsules can create problems for patients with nausea or difficulty swallowing; syringes can carry risk of infection; and even certain drugs administered from vials can take excessive time to [...]

903, 2018

3 Surprising Areas in Which Solid State Chemistry Is Rapidly Evolving

By | March 9th, 2018|Categories: Preformulation & Solid State Chemistry|Tags: , , |0 Comments

Active pharmaceutical ingredients (APIs) can take a wide variety of solid-state forms, from pure crystals to hydrates and salts. Polymorphs of these forms further complexify solid-state screening, by increasing the difficulty of identifying crystalline variations that are both useful and unique. However, the field of solid-state screening is rapidly [...]

703, 2018

4 Key Advantages of Lyophilizing Your Active Pharmaceutical Ingredient

By | March 7th, 2018|Categories: Lyophilization|Tags: , |0 Comments

When a drug must be preserved over a long period under uncontrolled conditions, pharma developers turn to lyophilization. By removing residual moisture without applying intense heat, safeguards active pharmaceutical ingredients (APIs) in the five following ways: 1. It increases the stability of your API. Lyophilized APIs remain stable much [...]

603, 2018

6 Critical Features of a Sterile Fill-and-Finish Cleanroom

By | March 6th, 2018|Categories: Generic & Commercial Drug Manufacturing Services, Parenteral & Syringe Manufacturing|Tags: , , |0 Comments

Sterile drugs are crucial as treatments for patients with compromised immune systems. However, the manufacture of sterile drugs demands extraordinary attention to detail, not only in terms of equipment and processes, but in the design of the cleanroom itself. A sterile fill-and-finish cleanroom must provide all of the following [...]

2702, 2018

Ocular Drug Delivery Systems

By | February 27th, 2018|Categories: Formulation Development & Clinical Trial Materials, Generic & Commercial Drug Manufacturing Services|Tags: , , , , , , |0 Comments

Conventional drug delivery vehicles are giving way to innovative systems, but much research remains to be done on these novel technologies. The human eye contains a striking amount of intricacy for such a small organ; and disorders affecting the eye can affect its components in a wide variety of ways. [...]