Solid Dispersions

Current estimates show that more than 30% of new chemical entities require solubilization technology to achieve sufficient efficacy in clinical trials.  Solid dispersion technology is a preferred formulation option to improve solubility and dissolution rates of these types of insoluble compounds.

The solubility issues that complicate the delivery of many poorly water-soluble NCEs today also affect the delivery of many already existing drugs.  There are various techniques available for enhancement of solubility and bioavailability.  For that reason, solid dispersions are one of the most promising dosage forms available.

Solid dispersions are a group of solid products consisting of at least two components: generally a hydrophilic matrix and a hydrophobic drug compound.  The drug compound can be dispersed in amorphous particles (clusters) or in crystalline particles.

Amorphous Solid Dispersion Screening

We can provide amorphous solid dispersion (ASD) screening to assess potential compound/polymer combinations and detect any potential risks in the resulting dispersions.  Our aim is to offer clients the information and data they need to make informed decisions on polymer selection and the next step in the development process.

VxP Pharma manufacturing services offer flexibility for a wide variety of solid dispersion forms and provide consistency in the final product that your project requires.  We can seamlessly tailor the specifications and packaging of your solid dispersion to suit your needs. Support from our manufacturing staff and development experts will ensure you quickly receive the best formulation of your specific drug compound.

It’s our goal to provide you with the manufacturing resources and analytical capabilities to keep your project on time and on budget. We offer a full range of solid dispersion manufacturing services.

Our state-of-the-art labs are staffed by some of the best trained and most experienced subject matter experts in the field.