ADME Studies2018-01-12T20:06:04+00:00

VxP Pharma offers custom-designed ADME studies in multiple animal species, using both cold and radiolabeled test materials with multiple administration routes to choose from.

Our experienced scientists routinely perform mass balance and tissue distribution studies to determine tissue half-life, clearance rates, and potential sites of toxicity after systemic exposure.  These studies are all managed by the QA department to provide complete electronic data collection, verification and evaluation for every project.

We have experience with common Isotopes, including Carbon-14, Tritium, and Iodine-125.  If your project requires custom radiosynthesis, our team can provide those capabilities as well as manage re-purification and radio-dilution of radiolabeled test materials if needed.  Our ADME sservices can also be integrated with metabolite profiling and identification using HPLC, mass spectrometry, dose formulation analysis, and bioanalysis. Please contact us for a current instrument list.

Studies conducted include:

  • Plasma kinetics
  • Excretion balance
  • Quantitative tissue distribution (traditional methods and QWBA)
  • Bioavailability
  • Micro-autoradiography (to determine cellular distribution)
  • Placental transfer
  • Various surgical models

The exceptional team of scientists including toxicologists, pathologists, veterinary surgeons, regulatory specialists, and support personnel have designed and performed multiple ADME studies with a variety of different animal models.  Specifically tailored, individual study designs enable our clients to quickly meet their product development goals.

The state-of-the-art labs are staffed by some of the best trained and most experienced subject matter experts in the field.

Contact us today for a free consultation with the scientific team and discover how VxP can be a valuable resource and partner for your organization.