Our lab can provide several developable salt forms through extensive salt screening and a thorough selection program. The salt screening protocol we have developed is able to rapidly identify a vast array of pharmaceutically acceptable salts. For example, selection of appropriate counter ions needs to be considered when forming API salts; consideration is based on a variety of factors including solubility, dissociation constants, and frequency of a salt’s use in approved drugs. Please call us for additional details.
We can provide our customers with screening services including:
- Researching available toxicology data
- Determining market precedence
- pKa of the API
- Development of formulation plans
Prior to beginning a study, a detailed understanding of the chemical and physical properties of the study candidate is essential. This enables an efficient coverage of the relevant chemical space during experimental design and salt selection. After we have achieved identification of a salt form, we will test properties such as stability and dissolution rate, with the goal of preparing a pure, safe salt form for each active pharmaceutical ingredient, an early step in creation of a scalable pharmaceutical.
The state-of-the-art labs are staffed by some of the best trained and most experienced subject matter experts in the field.